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  "Title": "Simple Method to Detect Compositional Changes in Genomic\nSequences",
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  "Date": "2024-09-27",
  "Authors@R": "c(person(\"Nora\", \"M. Villanueva\",email= \"nmvillanueva@uvigo.gal\", role = c(\"aut\", \"cre\"),\ncomment = c(ORCID = \"0000-0001-8085-2745\")),\nperson(\"Marta\", \"Sestelo\",email= \"sestelo@uvigo.gal\", role = \"aut\", comment = c(ORCID = \"0000-0003-4284-6509\")),\nperson(\"Alan\", \"Miller\", role = \"ctb\", comment = c(\"FORTRAN code lsq.f90: weighted least-squares module\"))\n)",
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  "Description": "This software is useful for loading '.fasta' or '.gbk'\nfiles, and for retrieving sequences from 'GenBank' dataset\n<https://www.ncbi.nlm.nih.gov/genbank/>. This package allows to\ndetect differences or asymmetries based on nucleotide\ncomposition by using local linear kernel smoothers. Also, it is\npossible to draw inference about critical points (i. e. maximum\nor minimum points) related with the derivative curves.\nAdditionally, bootstrap methods have been used for estimating\nconfidence intervals and speed computational techniques\n(binning techniques) have been implemented in 'seq2R'.",
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  "Packaged": {
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    "genome-analysis",
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        "seq2R"
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    },
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